Warfarin is one member of the anticoagulant class that presents a challenge to clinicians. Low-molecular weight heparins can be equally tricky, especially when it comes to dosing decisions in the obese, the renally compromised, and in patients with evolving pharmacokinetic profiles. How can we tailor our clinical approach to specific subtypes of patients who require anticoagulant therapy? Dr. Kate Phillips, clinical specialist in cardiology and anticoagulation at the Boston Medical Center, details special considerations for our approach to care. Dr. Charles Turck hosts.