Uterine fibroids and endometriosis are common gynecologic diseases that often cause pain, distress, and decreased quality of life. Unfortunately, they are often dismissed by clinicians as minor conditions. Traditional treatment options have included surgery, hormone therapy, radiation, and medical therapies. But now, gonadotropin-releasing hormone (GnRH) antagonists are proving to be an effective and well-tolerated alternative to invasive procedures. This real-world simulation reviews these emerging therapies and approaches for aligning patient priorities and desires with individualized treatment options.