Lung cancer is the leading cause of cancer death. Approximately 85% of lung cancer cases are non–small cell lung cancer (NSCLC), 10% to 15% of which are epidermal growth factor receptor (EGFR) mutation positive. The development of EGFR inhibitors (eg, tyrosine kinase inhibitors [TKIs]) has led to targeted therapy, advancing the management of NSCLC. Unfortunately, the disease often develops resistance to some of these therapies; however, significant progress has been made in the treatment of NSCLC.
Recent advances in next-generation EGFR TKIs have shown promising results in patients with EGFR mutation–positive refractory NSCLC.
This activity provides learners with information regarding recent advances in the identification of predictive biomarkers and the EGFR TKI treatment paradigm, efficacy and safety information about approved and emerging TKIs used to treat EGFR mutation–positive NSCLC, and provides some insight into how healthcare clinicians can help educate patients and their caregivers about this topic.