Holding Court in Pulmonary Hypertension

Overview
Patients with congenital heart disease are increasingly surviving into adulthood. For patients with single ventricle anatomy, pulmonary blood flow is dependent on central venous pressure with little or no ventricular support. Patients who have undergone Fontan surgery and progress to adulthood frequently develop increased pulmonary vascular resistance, which impacts ventricular function in a precapillary pulmonary hypertension phenotype.

This court case will explore the central question should these patients be placed on Group 1 vasodilator therapy. This pro/con debate will place you, the audience, in the role of the juror to decide the outcome. Evidence is presented, and expert witnesses queried the pluses and minuses of this therapeutic approach to maintaining physical function and quality of life in Fontan patients.
Target Audience
This activity has been designed to meet the educational needs of the interprofessional team, including physicians, nurses, and pharmacists, involved in the management of patients with congenital heart disease.
Learning Objectives
After participating in this educational activity, participants should be better able to:
- Understand the fundamental aspects of adult congenital heart disease with univentricular physiology
- Debate the hemodynamic aspects of Fontan physiology and its failure
- Review current information on the use of Group 1 vasodilator therapies in the adult Fontan patient
- Discuss the negative aspects of Group 1 vasodilator therapy in the adult Fontan patient
Accreditation Statement
In support of improving patient care, this activity has been planned and implemented by Global Learning Collaborative (GLC) and TotalCME, Inc. GLC is jointly accredited by the American Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE) and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team.

This activity was planned by and for the healthcare team, and learners will receive 1.0 Interprofessional Continuing Education (IPCE) credit for learning and change.
Faculty Disclosure of Commercial Relationships
In accordance with the ACCME Standards for Integrity and Independence, Global Learning Collaborative (GLC) requires that individuals in a position to control the content of an educational activity disclose all relevant financial relationships with any ineligible company. GLC mitigates all conflicts of interest to ensure independence, objectivity, balance, and scientific rigor in all educational programs.

The following faculty have disclosed:

Richard Krasuski, MD, faculty for this educational event, receives research funds from Actelion/Janssen, Edwards Lifesciences, Corvia, CryoLife and Medtronic; and receives consulting fees from Actelion/Janssen and Gore Medical.

Jamil A. Aboulhosn, MD, faculty for this educational event, receives research funds from Edwards Lifesciences, Abbott Inc, Janssen and Medtronic; and receives consulting fees from Medtronic and Edwards Lifesciences.

Joseph Kay, MD, faculty for this educational event, has no relevant financial relationships with ineligible companies.

Alexander Opotowsky, MD, MMSc, faculty for this educational event, serves as a committee member for the Independent Data and Monitoring Committee for Johnson and Johnson/Janssen.

Wayne J. Franklin, MD, FACC, faculty for this educational event, has no relevant financial relationships with ineligible companies.

Jean Elwing, MD, faculty for this educational event, receives research funds from Actelion/Janssen, Reata, United Therapeutics, Liquidia, Phase Bio, Complexa, Gossamer Bio, Bayer, Acceleron, Altavant, Arena, Aerovate and Lung LLC; and receives consulting fees from Acceleron, Janssen, United Therapeutics, Altavant, Aerovate, Bayer, Gossamer Bio and Liquidia.
Planners and Managers Disclosure List
The following planners/reviewers/managers have disclosed:

Dixon W. Wilde, PhD, FAHA, planner for this educational event, has no relevant financial relationships with ineligible companies.

William Mencia, MD, FACEHP, CHCP, reviewer for this educational event, has no relevant financial relationships with ineligible companies.

TotalCME, Inc. planners and managers have no relevant commercial relationships to disclose.

All the relevant financial relationships for these individuals have been mitigated.
Disclaimer
The views and opinions expressed in this educational activity are those of the faculty and do not necessarily represent the views of GLC and TotalCME, Inc. This presentation is not intended to define an exclusive course of patient management; the participant should use his/her clinical judgment, knowledge, experience, and diagnostic skills in applying or adopting for professional use any of the information provided herein. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient's conditions and possible contraindications or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities. Links to other sites may be provided as additional sources of information. Once you elect to link to a site outside of MedEd On The Go you are subject to the terms and conditions of use, including copyright and licensing restrictions, of that site.

Reproduction Prohibited
Reproduction of this material is not permitted without written permission from the copyright owner.
Acknowledgment
This activity is supported by an educational grant from Actelion Pharmaceuticals US, Division of Janssen Pharmaceuticals.
Jointly provided by Global Learning Collaborative (GLC) and TotalCME, Inc.
Fee Statement
This activity is FREE to all participants.
Instructions for Completion
During the period 10/28/2022 through 10/28/2023, registered participants wishing to receive continuing education credit for this activity must follow these steps:
1. Read the learning objectives and faculty disclosures.
2. Answer a pre-program question.
3. View the program.
4. Complete the post-test with a score of 100%.
5. Complete activity evaluation.
6. Apply for credit and either bank your credits or print your certificate.
For Pharmacists: Upon successfully completing the post-test with a score of 100% and the activity evaluation form, transcript information will be sent to the NABP CPE Monitor Service. This may require you to add or update the e-profile ID/date of birth information saved in your account.
System Requirements
Our site requires a computer, tablet, or mobile device and a connection to the Internet. For best results, a high-speed Internet connection is recommended (DSL/Cable/Fibre). We also recommend using the latest version of your favorite browser to ensure compliance with W3C standards, such as Chrome, Safari, Firefox, or Microsoft Edge.
Publication Dates
Release Date: 10/28/2022
Expiration Date: 10/28/2023