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Highlights from the 13th International Congress of the Society for Melanoma Research: A Focus on Resistance

Updates on innate and acquired therapeutic resistance as presented at this year’s Society for Melanoma Research Congress

Available credits: 0.25

Time to complete: 15 minutes


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  • Overview

    Melanomas are among the most genetically abnormal malignancies with hundreds or even thousands of mutations.  In this activity, Dr. Meenhard Herlyn discusses updates on resistance from the 13th International Congress of the Society for Melanoma Research that took place recently in Boston, Massachusetts. Topics include, therapy strategies that benefit from many mutations, how melanomas adapt to growth outside of the human host, and their response to MAPK inhibitors. He will also discuss tumor heterogeneity and drug resistance and why checkpoint inhibitors and kinase inhibitors are ideal for combination therapies.

  • Disclosure of Conflicts of Interest

    In accordance with the ACCME Standards for Commercial Support, The Omnia-Prova Education Collaborative (TOPEC) requires that individuals in a position to control the content of an educational activity disclose all relevant financial relationships with any commercial interest. TOPEC resolves all conflicts of interest to ensure independence, objectivity, balance, and scientific rigor in all its educational programs.

    Meenhard Herlyn, DVM, DSc
    Wistar Institute
    Philadelphia, PA

    Dr. Herlyn has contracted research with Actelion, Ltd., Macrophage Therapeutics and Plexxikon.


    • Sean T. Barrett, has nothing to disclose.
    • Matt Birnholz, MD, has nothing to disclose.
    • Colleen Braun has nothing to disclose.
    • Barry A. Fiedel, PhD has nothing to disclose.
    • Kia K. Gray, MPH has nothing to disclose.

    Planners and Managers
    The PIM planners and managers, Trace Hutchison, PharmD, Samantha Mattiucci, PharmD, CHCP, Judi Smelker-Mitchek, MBA, MSN, RN, and Jan Schultz, MSN, RN, CHCP have nothing to disclose.

  • Learning Objectives

    After participating in this educational activity, participants should be better able to:

    • Discuss therapy strategies for abnormal malignancies that may have hundreds or thousands of mutations.
    • Describe the major reasons melanomas readily adapt to growth outside of the human host, and why understanding that is important.
    • Identify common characteristics of melanomas treated with MAPK inhibitors, such as those for BRAFV600E, MEK, or ERK.
    • Employ strategies to design second line therapies after the development of resistance.
    • Recognize the reason why checkpoint inhibitors induce a response in 30-45% of patients, as well as the main reason for non-response, and their potential in combination therapy.
  • Target Audience

    This activity is designed to meet the educational needs of oncologists, pharmacists, and registered nurses.

  • Accreditation and Credit Designation Statements

    The Omnia-Prova Education Collaborative, Inc. is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

    The Omnia-Prova Education Collaborative, Inc. designates this enduring material for a maximum of .25 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

    Continuing Pharmacy Education

    Postgraduate Institute for Medicine is accredited by the Accreditation Council for Pharmacy Education as a provider of continuing pharmacy education.

    Postgraduate Institute for Medicine designates this continuing education activity for 0.25 contact hour(s) (0.025 CEUs) of the Accreditation Council for Pharmacy Education.

    (Universal Activity Number – 0809-9999-16-535-H01-P) 
    Type of Activity: Knowledge
    ACPE release date: November 28, 2016

    For Pharmacists: Upon successfully completing the activity evaluation form, transcript information will be sent to the NABP CPE Monitor Service. 

    Continuing Nursing Education

    The Postgraduate Institute for Medicine is accredited as a provider of continuing nursing education by the American Nurses Credentialing Center's Commission on Accreditation.  This educational activity for 0.5 contact hour(s) is provided by the Postgraduate Institute for Medicine.

    For Pharmacists and Nurses:

    If you wish to receive acknowledgment for completing this activity, please complete the evaluation on  On the navigation menu, click on “Find Post-test/Evaluation by Course” and search by course ID 12097.  Upon registering and successfully completing the activity evaluation, your certificate will be made available immediately.  

  • Provider(s)/Educational Partner(s)


    Prova Education designs educational activities based on evidence-based medicine, needs and gaps analyses, learner feedback, and more. Its mission is to serve as an innovative and relevant resource for clinical content and educational interventions across a broad spectrum of specialties.

    Prova Education

    Co-provided by Postgraduate Institute for Medicine and Prova.


  • Commercial Support

    This activity is supported by an independent educational grant from Merck.

  • Disclaimer

    The views and opinions expressed in this educational activity are those of the faculty and do not necessarily represent the views of TOPEC and Prova Education. This presentation is not intended to define an exclusive course of patient management; the participant should use his/her clinical judgment, knowledge, experience and diagnostic skills in applying or adopting for professional use any of the information provided herein. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patients’ conditions and possible contraindications or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities. Links to other sites may be provided as additional sources of information. Once you elect to link to a site outside of Prova Education you are subject to the terms and conditions of use, including copyright and licensing restriction, of that site.

    Reproduction Prohibited
    Reproduction of this material is not permitted without written permission from the copyright owner.

  • System Requirements

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