Changing the Treatment Paradigm: Taking a Targeted Approach to Treating Non-Advanced Systemic Mastocytosis

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Expert Insights Into the Epidemiology, Diagnosis, and Treatment of Non-Advanced Systemic Mastocytosis

Changing the Treatment Paradigm: Taking a Targeted Approach to Treating Non-Advanced Systemic Mastocytosis

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  • Overview

    Systemic mastocytosis (SM) is a rare heterogeneous disease characterized by clonal expansion and accumulation of neoplastic mast cells in one or more organs (most commonly bone marrow with or without skin involvement). Most patients with SM have non-advanced disease (indolent and smoldering subtypes) for which there are currently no FDA-approved therapies that address the underlying pathogenesis of the disease. Given its rarity, many clinicians are not aware of the unique clinical features, disease burden, or the recent updates to the World Health Organization (WHO) diagnostic and subtyping criteria for SM, resulting in long delays in diagnosis and suboptimal care in clinical practice. Taken together, these practice gaps highlight a need for evidence-based, up-to-date continuing education activities for clinicians on optimal diagnosis and management of non-advanced SM.

  • Target Audience

    This activity has been designed to meet the educational needs of the interprofessional team, including hematologists/oncologists, pathologists, nurses, pharmacists, immunologists, allergists, dermatologists, as well as other clinicians involved in the management of patients with non-advanced systemic mastocytosis.

  • Learning Objectives

    After participating in this educational activity, participants should be better able to:

    • Discuss the clinical features, disease burden, and recommended workup for the diagnosis and subtyping of systemic mastocytosis
    • Evaluate current and emerging approaches for the management of non-advanced systemic mastocytosis
  • Accreditation Statement

    In support of improving patient care, this activity has been planned and implemented by Global Learning Collaborative (GLC) and TotalCME, Inc. GLC is jointly accredited by the American Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE) and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team.

    This activity was planned by and for the healthcare team, and learners will receive 1.25 Interprofessional Continuing Education (IPCE) credits for learning and change.

  • Faculty Disclosure of Commercial Relationships

    In accordance with the ACCME Standards for Integrity and Independence, Global Learning Collaborative (GLC) requires that individuals in a position to control the content of an educational activity disclose all relevant financial relationships with any ineligible company. GLC mitigates all conflicts of interest to ensure independence, objectivity, balance, and scientific rigor in all educational programs. 

    The following faculty have disclosed:

    Mariana C. Castells, MD, PhD, faculty for this education event, has no relevant financial relationships with ineligible companies.

    Matthew P. Giannetti, MD, faculty for this education event, receives research support from Blueprint Medicines; and receives consulting fees from Cogent Biosciences. 

  • Planners and Managers Disclosure List

    The following planners/reviewers/managers have disclosed:

    Megan Reimann, PharmD, BCOP, planner for this educational event, has no relevant financial relationships with ineligible companies.

    William Mencia, MD, FACEHP, CHCP, reviewer for this educational event, has no relevant financial relationships with ineligible companies.

    TotalCME, Inc. planners and managers have no relevant commercial relationships to disclose.

    All the relevant financial relationships for these individuals have been mitigated.

  • Disclaimer

    The views and opinions expressed in this educational activity are those of the faculty and do not necessarily represent the views of GLC and TotalCME, Inc. This presentation is not intended to define an exclusive course of patient management; the participant should use his/her clinical judgment, knowledge, experience, and diagnostic skills in applying or adopting for professional use any of the information provided herein. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient's conditions and possible contraindications or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities. Links to other sites may be provided as additional sources of information. Once you elect to link to a site outside of MedEd On The Go you are subject to the terms and conditions of use, including copyright and licensing restrictions, of that site.

    Reproduction Prohibited
    Reproduction of this material is not permitted without written permission from the copyright owner.

  • Acknowledgment

    This activity is supported by an independent educational grant from Blueprint Medicines Corporation.

    Jointly provided by Global Learning Collaborative (GLC) and TotalCME, Inc.

  • Fee Statement

    This activity is FREE to all participants.

  • Instructions for Completion

    During the period 12/21/2022 through 12/21/2023, registered participants wishing to receive continuing education credit for this activity must follow these steps:

    1. Read the learning objectives and faculty disclosures.
    2. Answer a pre-program question.
    3. View the program.
    4. Complete the post-test with a score of 100%.
    5. Complete activity evaluation.
    6. Apply for credit and either bank your credits or print your certificate.
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Schedule29 Nov 2023