Autoimmunity has been identified in over 100 separate diseases. Depending on the target tissues, these disorders may be systemic, localized, or perhaps somewhere in between. The characteristics of autoimmune pancreatitis represent one such example of diffuse-to-localized disorders, and is the subject of this discussion. New forms of imaging enable us to map the inflammatory components of this and other diseases, often identifying conditions that were not part of the original differential diagnosis. How does this both aid and complicate management strategies for patients? Host Dr. Jason Birnholz welcomes Dr. Dushyant Sahani, clinical instructor of radiology at Harvard Medical School and director of CT imaging services at Massachusetts General Hospital, to share insights and expertise on imaging autoimmune pancreatitis.