Impact and Effectiveness of the Quadrivalent Human Papillomavirus Vaccine: A Systematic Review of 10 Years of Real-world Experience
Clinical Infectious Disease 16 Aug 15;63(4):519-27. doi: 10.1093/cid/ciw354. Epub 2016 May 26.
Garland SM1, Kjaer SK2, Muñoz N3, Block SL4, Brown DR5, DiNubile MJ6, Lindsay BR6, Kuter BJ6, Perez G7, Dominiak-Felden G8, Saah AJ6,Drury R8, Das R6, Velicer C6.
Prophylactic human papillomavirus (HPV) vaccination programs constitute major public health initiatives worldwide. We assessed the global effect of quadrivalent HPV (4vHPV) vaccination on HPV infection and disease. PubMed and Embase were systematically searched for peer-reviewed articles from January 2007 through February 2016 to identify observational studies reporting the impact or effectiveness of 4vHPV vaccination on infection, anogenital warts, and cervical cancer or precancerous lesions. Over the last decade, the impact of HPV vaccination in real-world settings has become increasingly evident, especially among girls vaccinated before HPV exposure in countries with high vaccine uptake. Maximal reductions of approximately 90% for HPV 6/11/16/18 infection, approximately 90% for genital warts, approximately 45% for low-grade cytological cervical abnormalities, and approximately 85% for high-grade histologically proven cervical abnormalities have been reported. The full public health potential of HPV vaccination is not yet realized. HPV-related disease remains a significant source of morbidity and mortality in developing and developed nations, underscoring the need for HPV vaccination programs with high population coverage.
© The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America.
Susan J. Wysocki, WHNP, FAANP
This activity is supported by an independent educational grant from Merck.