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Dr. Scott Waldman received his PhD in 1980 from the department of anatomy at Thomas Jefferson University in Philadelphia and pursued postdoctoral training in the division of clinical pharmacology at Stanford University. In 1987, he obtained his MD from Stanford, followed by residency training in internal medicine at the Stanford University Hospital. In 1993 he returned to Thomas Jefferson University as an assistant professor in the departments of internal medicine and biochemistry and molecular pharmacology, becoming director of the division of clinical pharmacology in 1997. In 2000, he was appointed professor of internal medicine and biochemistry and molecular pharmacology and was awarded the Samuel MV Hamilton Endowed Chair.

Dr. Waldman has been the director of the Molecular Targets and Developmental Therapeutics Program, and currently directs the Gastrointestinal Cancer Program of the Kimmel Cancer Center of Thomas Jefferson University. In July 2005, he was appointed as the chair of the Department of Pharmacology and Experimental Therapeutics. Dr. Waldman has chaired scientific review panels for the NIH, is a member of editorial boards for scholarly journals.

Dr. Waldman is a clinician scientist whose research interests range from the molecular biology of signal transduction to diagnostics and therapeutics for gastrointestinal cancer. His investigations, utilizing a combination of cellular, molecular and pharmacological approaches, have focused on understanding the role of guanylyl cyclase C in colorectal cancer. This enzyme is selectively expressed in intestinal epithelial cells and Dr. Waldman has explored the utility of guanylyl cyclase C ligands as novel antineoplastic agents in the treatment of metastatic human colorectal cancers. His recent studies have centered on targeting of colorectal tumors using heat stable enterotoxin that activates guanylyl cyclase C. Dr. Waldman's studies provide a basis for novel diagnostic and therapeutic approaches for the treatment of a condition that is a leading cause of cancer and cancer-related mortality in the world.