ReachMD

Clark D. West Chair of NephrologyDirector, Nephrology Fellowship Training ProgramAssociate Program Director for Research and Academic Careers at Cincinnati Children's Hospital Medical Center. Dr. Bissler's science interests revolve around DNA biochemistry and the role of intrinsic DNA instability leading to disease. His work has identified several inherited diseases that have renal involvement that can be explained by alternative DNA structure mutagenesis. These structures include A-B helix transitions, cruciform extrusion and triplex DNA formation. His major focus is on DNA directed mutagenesis within the PKD1 gene. Mutations in this gene lead to autosomal dominant polycystic kidney disease. Dr. Bissler's clinical research focus revolves around the computerization of hemodialysis and hemofiltration. Specifically, Drs. Bissler and Marios Polycarpou at the Department of Electrical and Computer Engineering, University of Cincinnati, are working with adaptive and intelligent control systems as applied to pediatric nephrology procedures. These control algorithms can both control and learn from experience smoothing procedures with easing of physician and nurse time demands.