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Silicone-Based Scar Cream Effective in Upper Eyelid Blepharoplasty

Silicone-Based Scar Cream Effective in Upper Eyelid Blepharoplasty

Persons undergoing upper eyelid blepharoplasty incisions may benefit from the early use of a silicone-based scar cream, according to recent study results published in the Journal of Drugs and Dermatology. A silicone-based cream can reduce cicatricial and hypertrophic scarring.

This single-surgeon, retrospective study included 272 eyelids, 132 of which did not receive treatment after cosmetic upper eyelid blepharoplasty and 140 of which received SKN2017B, a silicone-based scarring cream with selective growth factor. Persons treated with SKN2017B applied the cream 2×/d for 3 months. The researchers compared the 2 groups for the incidence of triamcinolone/5-fluorouracil (5-FU) injections into areas of hypertrophic and cicatricial changes using a version of the Vancouver Scar Study Scale. They used a Student’s t-test to perform statistical analysis.

Investigators administered intralesional triamcinolone/5-FU injections to 43.9% of eyelids that were not treated with SKN2017B but gave injections to only 22.9% of treated eyelids (P <.05). They reported no adverse reactions in either cohort. Researchers administered 113 intralesional injections (73.5% by 1 month, 17.7% by 2 months, 4.4% by 3 months, 3.5% by 5 months, and 0.9% by 6 months) in the 6-month follow-up period. All participants achieved grade ≥1 on the Vancouver Scar Study Scale’s pliability and height metrics.

Limitations to this study included a variance of intralesional wound modulation between surgeons, as well as a lack of assessment of other scarring-related issues and suture type.

The study researchers concluded that “surgeons that pay particular attention to the quality of scars may benefit from using a silicone cream based scar cream that has proven effective in wound healing. Furthermore, patients that are not able to follow-up as frequently as desired due to various situations (long-distance travel, employment reasons) may benefit from a topical scar cream that can reduce the likelihood of post incisional cicatricial or hypertrophic changes.


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