Photo: Novateur Ventures
A new study by Novateur Ventures provides a comparative analysis of twelve COVID-19 Vaccines that had initiated or announced the Phase III clinical trial stage by early November 2020. The study highlights the early successes, as well as the hurdles and barriers yet to be overcome for ending the global COVID-19 pandemic.
COVID-19 vaccines analyzed for the study
The study 'Target Product Profile Analysis of COVID-19 Vaccines in Phase III Clinical Trials and Beyond: An Early 2021 Perspective' appears in the Special Issue "Vaccines and Therapeutics against Coronaviruses" of the journal Viruses, an international peer-reviewed, open-access journal published monthly by the Multidisciplinary Publishing Institute (MDPI).
"The global concerted effort to develop vaccines to fight COVID-19 and deliver it to millions of citizens around the world in less than a year is an unprecedented feat in the history of medicine and a triumph for vaccine research and development said study co-author Ali Ardakani, Founder & Managing Director at Novateur Ventures. "Vaccination-mediated herd immunity will play a key role in helping us in returning to a world unhampered by restrictions and to global prosperity."
COVID-19 Vaccines belonging to four different platforms were analyzed in five different categories using a "harmonized" target product profile (TPP) version of guidance from the World Health Organization, Coalition for Epidemic Preparedness Innovations (CEPI) and Center for Biologics Evaluation and Research (CBER). Key analysis from the study:
"Ten out of twelve vaccines we analyzed have already received some form of authorization for use in different countries in a period of less than a year. This is a remarkable achievement," said study co-author Colin D. Funk, Scientific Lead at Novateur Ventures. "We hope that SARS-CoV-2 viral variants, emerging at an alarming rate in various countries, will not derail the successful vaccine efforts to date."
The study has also identified three main barriers/hurdles for ending the global COVID-19 pandemic -
"The process of developing a vaccine from scratch normally takes place over several years but it's truly amazing that we already have approved vaccines to fight the spread of COVID-19. This speaks volumes about the efforts various countries have put into pandemic preparedness and response," said co-author Craig Laferrière, Head Vaccine Development at Novateur Ventures. This was made possible through concurrent pre-clinical and early Phase I studies, strategic risk measures, and adaptive trial designs."