menu

ReachMD

Be part of the knowledge.
Register

We’re glad to see you’re enjoying ReachMD…
but how about a more personalized experience?

Register for free

Negative Fecal Tests Tied to Low Risk for Advanced Colorectal Cancer

ReachMD Healthcare Image
02/03/2023
medicalxpress.com

by Lori Solomon

There was a low risk for advanced neoplasia after multiple rounds of negative fecal immunochemical tests (FIT) in people undergoing surveillance colonoscopy, according to a study published online Jan. 4 in Clinical Gastroenterology and Hepatology.

Molla M. Wassie, Ph.D., from Flinders University in Bedford Park, Australia, and colleagues examined the relationship between number of rounds of negative FIT and the risk for advanced neoplasia in individuals undergoing surveillance colonoscopy. The analysis included 3,369 individuals (aged 50 to 74 years) who had completed a two-sample FIT between colonoscopies with each round having a negative result (<20 μg hemoglobin/g feces).

The researchers found that the incidence of advanced neoplasia in the cohort was 9.9 percent and decreased with increasing numbers of rounds of negative FIT results (11.1 percent after one negative FIT to 5.7 percent after four negative tests). Compared with only one negative FIT, the risk for advanced neoplasia was significantly lower in participants with three (subdistribution hazard ratio [SHR], 0.50) and four (SHR, 0.33) rounds of negative FIT.

"This supports the use of interval FIT to personalize surveillance by lengthening colonoscopy intervals following multiple negative FIT results," the authors write.

Two authors disclosed financial ties to the company that provided the fecal immunochemical tests used in the study.

More information: Molla M. Wassie et al, Multiple negative faecal immunochemical tests reduce risk of advanced neoplasia in a colonoscopy surveillance program, Clinical Gastroenterology and Hepatology (2023). DOI: 10.1016/j.cgh.2022.12.024

Copyright © 2023 HealthDay. All rights reserved.

Citation: Negative fecal tests tied to low risk for advanced colorectal cancer (2023, January 31) retrieved 31 January 2023 from https://medicalxpress.com/news/2023-01-negative-fecal-advanced-colorectal-cancer.html

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Facebook Comments

Schedule29 Mar 2024