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Welcome to the Advanced Liver Disease Initiative

Welcome to the Advanced Liver Disease Initiative

Initiative Chairperson

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Patients in advanced stages of liver failure can experience a range of extrahepatic complications and organ failures as their cirrhosis decompensates. Chief among these is kidney failure, which confers significantly increased risk of mortality to patients who are awaiting liver transplant.

Gastroenterologist, nephrologist, and critical care professionals work together to manage these patients using all the tools in the toolbox to keep patient’s organ systems functioning optimally through transplant.

Maintaining organ function, especially kidney function, can lead to better outcomes post-transplant. In these activities, we will review current guidelines and discuss expert practice strategies for these patients as a multidisciplinary team.

Resource Center

Discover a curated collection of foundational, practical, and real-world educational resources at your fingertips. Click on a link to get started.

NKF Kidney Professionals Resource Page

Visit the National Kidney Foundation’s resource page for professionals. Find education, tools, and resources to improve your practice.

Acute kidney injury in patients with cirrhosis: Acute Disease Quality Initiative (ADQI) and International Club of Ascites (ICA) joint multidisciplinary consensus meeting

Nadim MK, Kellum JA, Forni L, et al. Acute kidney injury in patients with cirrhosis: Acute Disease Quality Initiative (ADQI) and International Club of Ascites (ICA) joint multidisciplinary consensus meeting. Journal of Hepatology. 2024;81(1):163-183. doi:10.1016/j.jhep.2024.03.031

Acute-on-Chronic Liver Failure Clinical Guidelines

Bajaj JS, O’Leary JG, Lai JC, et al. Acute-on-Chronic Liver Failure Clinical Guidelines. The American Journal of Gastroenterology. 2022;117(2):225-252. doi:10.14309/ajg.0000000000001595

Steering Committee

Nancy Reau, MD

Nancy Reau, MD

Associate Director of Solid Organ Transplantation
Richard B. Capps Chair of Hepatology
Rush University Medical Center
Chicago, Illinois

Andrew Allegretti, MD, MSc

Andrew Allegretti, MD, MSc

Director of Critical Care Nephrology
Principal Investigator, MGH Kidney Research Center
Massachusetts General Hospital
Boston, Massachusetts

Kevin Regner, MD

Kevin Regner, MD

Professor and Interim Chair
Department of Medicine
Medical College of Wisconsin
Milwaukee, Wisconsin

Ram Subramanian, MD

Ram Subramanian, MD

Professor of Medicine and Surgery
Director of Liver Critical Care Services
Emory University College of Medicine
Atlanta, Georgia

Jointly provided by

Supported by an educational grant from Mallinckrodt Pharmaceuticals